产品资料

P01240 – Fluorescent USPIO

 

P01240 – Fluorescent USPIO

580.00 

Category: Preclinical MRI probes

Description

Catalogue Number P01240
Description Bi-modal Ultra Small Particle of Iron Oxyde (USPIO) Guerbet Research Prototype designed for macrophage imaging. This compound is equivalent to P904 but contains also Rhodamine B for a fluorescent detection
Main Applications Cellular imaging: inflammation through macrophage imaging after i.v. injection (atherosclerotic plaque, Alzheimer disease, multiple sclerosis, osteo-arthritis…), metastatic lymph node imaging, liver tumor, in vitro cell labeling and cell trafficking
Molecular characteristics
–  Hydrodynamic size: diameter is 25-30 nm
–  Fe content : > 5000 Fe atoms per particle
–  Fluorescent content: 7 rhodamines per particle
–  Recommended dose: 200 to 1000 μmol/kg = 2.5 μL/g

Example: for a 30g body weight mouse injection, volume is 75 μL

 

–  Relaxivities ( s-1.mM-1, 37°C; 4% Human Albumin Serum, medium closed to plasma)
Bo(T)

1.5

3.0

4.7

7.0

r1

14

7

4

1.6

r2

90

90

92

94

–  Qualitative techniques: Perl’s staining
–  In vitro quantification techniques: P01240 is a Fe-based contrast agent. Thus, it is necessary to take into account the endoge- nous iron content for quantification in biological media by ICP- AES or ICP-MS. Another way for USPIO quantification is rela- xometry, which is poorly sensitive to endogenous iron content.
Characteristics of the vial –  Concentration: [Fe] = 4.47 mgFe/L

–  Volume: 450 μL (5 mice dose approx.)

–  Other animal species: contact us

Storage Need to be stored at 4°C in a closed vial away from light
Notes For in vitro or animal use only
Selected publications [1] Corot et al, ed. Molecular and Cellular MR Imaging: CRC Press, 2007 [2] Unpublished Guerbet data [3] Sigovan et al, Radiology 2009 [4] Raynaud et al, ISMRM 2010 [5] Luciani et al, Radiology 2012

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